Welcome to My Medical Notes (Foundation)

Assalamu'alaikum wbt. This is the second version of My Medical Notes blog where i put the notes during my medical student time. This page is reserved for topic covered during the foundation year including anatomy, physiology, biochemistry, ethics and some view points on Islamic medicine. Hope that you will get benefit from this blog. Please pray for me that i can achieve my dream to become an Emergency and Trauma Physician without any problem. T-Q

Muhamad Na'im B Ab Razak (jacknaim) is a Muslim Doctor graduated from Universiti Sains Malaysia and currently working as a housemanship officer in Hospital Tawau, Sabah. Ambitious in pursuing master program in emergency and traumatology medicine and loves to spent his free time joining humanitarian missions, writing and speaks as an amateur public speaker in motivation and comparative religion.

Saturday, July 23, 2011

Role of Ascorbic Acid and α-antitrypsin


Describe the importance of:

    1. ascorbic acid in collagen synthesis
    2. α-antitrypsin in elastin degradation (10minutes)


Ascorbic acid

-is a reducing agent

-require for action of prolyl hydroxylase and lysyl hydroxylase

-to produce hydroxyproline and hydroxylysine from hydroxylation of prolyl and lysyl

-important for formation of cross linking of collagen fiber

-if no asorbic acid or deficient, lead to Scurvy


α-antitrypsin

-inhibit a number of proteolytic enzyme that hydrolyze and destroy protein

-it has important role in inhibition of neutrophil elastase

-elastase can degrade elastin, therefore weaken structure like alveolar wall

-therefore, α-antitrypsin inhibit the action of elastase

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