Welcome to My Medical Notes (Foundation)

Assalamu'alaikum wbt. This is the second version of My Medical Notes blog where i put the notes during my medical student time. This page is reserved for topic covered during the foundation year including anatomy, physiology, biochemistry, ethics and some view points on Islamic medicine. Hope that you will get benefit from this blog. Please pray for me that i can achieve my dream to become an Emergency and Trauma Physician without any problem. T-Q

Muhamad Na'im B Ab Razak (jacknaim) is a Muslim Doctor graduated from Universiti Sains Malaysia and currently working as a housemanship officer in Hospital Tawau, Sabah. Ambitious in pursuing master program in emergency and traumatology medicine and loves to spent his free time joining humanitarian missions, writing and speaks as an amateur public speaker in motivation and comparative religion.

Saturday, July 23, 2011

Synthesis of Collagen

Image taken from WikiMedia [link]


1) Formation of pro- α-chain

2) Hydroxylation

3) Glycosylation

4) Assembly and secretion

5) Extracellular cleavage of procollagen molecule


-genes for pro α1 and α2 are transcribed into mRNA’s

-mRNA’s is transcribed to pre pro- α polypeptide chain that are extruded into ER

-Selected proline and lysine residues are hydroxylated

-Selected lysine residue are glycosylated with glucose and galactose

-Three pro-α- chain assembles #intra and inter disulfide bond form at C-terminal polypeptide extension

-Triple helix forms by zipper like folding

-Procollagen molecule secreted from golgi vacuole to ECM

-N terminal and terminal propeptides cleaved by procollagen peptidases

-Self assembly of collagen molecules into fibrils and subsequent cross linking


Picture Summary



Image taken from Oulun Yliopisto

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